Condezo YB, Sainz-Urruel R, Gomez L, Salas-Llore D, Felipe-Medinaa N, Bradley R, Wolff ID, Tanis S, Barberoe JL, Sánchez-Martín M, Nielsenh ML, Gonzalez-Prieto R, Cohen PE, Pendas AM, and Llano E. RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse. PNAS 121: 25(2024) DOWNLOAD
Horan TS, Ascencão CFR, Mellor C, Wang M, Smolka MB, Cohen PE. The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice. PLoS Genet 20(2): e1011175. (2024) DOWNLOAD
Alexander AK, Rice EJ, Lujic J, Simon LE, Tanis S, Barshad G, Zhu L, Lama J, Cohen PE, and Danko CG. A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis. Nature communications 14: 1753 (2023). DOWNLOAD
Brieno-Enriquez MA, Faykoo-Martinez M, Goben M, Grenier J, McGrath A, Prado A, Sinopoli J, Wagner K, Walsh P, Lopa S, Laird D, Cohen PE, Wilson M, Holmes M, and Place N. Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats. Nature Communications 14: 670 (2023) DOWNLOAD
Carro MLM, Grimson A, Cohen PE. Small RNAs and their protein partners in animal meiosis. Current Topics in Developmental Biology. (2023) DOWNLOAD
Wang S, Lee K, Gray S, Zhang Y, Tang C, Morrish RB, Tosti E, van Oers J, Amin MR, Cohen PE, MacCarthy T, Roa S, Scharff MD, Edelmann W, Chahwan R. Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice. Nucleic Acids Research 50(14):8093-8106 (2022) DOWNLOAD
Roy JCL, Vitalo A, Andrew MA, Mota-Silva E, Kovalenko M, Burch Z, Nhu AM, Cohen PE, Grabczyk E, Wheeler VC, Mouro Pinto R. Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection. Nucleic Acids Research 49(7):3907-3918 (2021) DOWNLOAD
Pereira A., Arroyo-Martinez G.A., Guo M.Z., Downey M.S., Kelly E.R., Grive K.J., Mahadevaiah S.K., Sims J.R., Faca V.M., Tsai C., Schiltz C.J., Wit N., Jacobs H., Clark N.L., Freire R., Turner J., Lyndaker A.M., Breino-Enriquez M.A., Cohen P.E., Smolka M.B., and Weiss R.S. Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. eLife 11: e68677 (2022) DOWNLOAD
Sims J.R., Faca V.M., Pereira C., Ascencao C., Comstock W., Bader J., Arroyo-Martinez G.A., Freire R., Cohen P.E., Weiss R.S., and Smolka M.B. Phosphoproteomics of ATR signaling in mouse testes. eLife 11: e68648 (2022) DOWNLOAD
Gray S., Santiago E.R., Chappie J.S., and Cohen P.E. Cyclin N-terminal domain-containing-1 coordinates meiotic crossover formation with cell cycle progression in a cyclin-independent manner. Cell Reports 32(1): 107858 (2020) DOWNLOAD
Toledo M., Sun X., Brieno-Enriquez M.A., Raghavan V., Gray S., Pea J., Milano C.R., Venkatesh A., Patel L., Borst P.L., Alani E., and Cohen P.E. A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLgamma during crossover formation in meiotic prophase I. PLOS Genetics 15(6): e1008177 (2019) DOWNLOAD
Milano C.R., Holloway J.K., Zhang Y., Jin B., Smith C., Bergman A., Edelmann W., and Cohen P.E. Mutation of the ATPase domain of MutS Homolog-5 (MSH5) reveals a requirement for a functional MutSgamma complex for all crossovers in mammalian meiosis. G3 (Bethesda) 9(16) 1839-1850 (2019) DOWNLOAD
Grive K.J., Hu Y., Shu E., Grimson A., Elemento O., Grenier J.K., and Cohen P.E. Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing. PLOS Genetics 15(3): e1007810 (2019) DOWNLOAD
Brieno-Enriquez M.A., Moak S.L., Abud-Flores A., and Cohen P.E. Characterizatio of Telomeric repeat-containing RNA (TERRA) localization and protein interactions in primordial germ cells of the mouse. Biology of Reproduction 100(4): 950-962 (2018) DOWNLOAD
Brieno-Enriquez M.A., Moak S.L., Holloway J.K., and Cohen P.E. NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between alpha-adducin and myosin X. PLoS One (2017) 12(10): e0185780 DOWNLOAD
Hilz S, Fogarty EA, Modzelewski A, Cohen PE, and Grimson A. Transcriptome profiling of the developing male germ line identifies the miR-29 family as a global regulator during meiosis. RNA Biology(2017) 14:219-235 DOWNLOAD
Gray S. and Cohen P.E. Control of meiotic crossovers: from double strand break formation to designation. Annual Review of Genetics (2016) 50: 175-210 DOWNLOAD
Brieno-Enriquez M.A., Moak S.L., Toledo M., Filter J.J., Gray S., Barbero J.L., Cohen P.E., and Holloway J.K Cohesin removal along the chromosome arms during the first meiotic division depends on a NEK1-PP1-WAPL axis in the mouse. Cell Reports (2016) 17:977-986 DOWNLOAD
Hilz S., Modzelewski A., Cohen P.E., & Grimson A. The roles of microRNAs and siRNAs in mammalian spermatogenesis [Revew]. Development (2016) 143: 3061-3073 PMID: 27578177 DOWNLOAD
Burkhardt S., Borsos M., Szydlowska A., Godwin J., Williams S.A., Cohen P.E., Hirota T., Saitou M., & Tachibana-Konwalski, K. Chromosome cohesion established by Rec8-cohesin in fetal oocytes is maintained without detectable turnover in oocytes arrested for months in mice. Current Biology (2016) 26: 678-685 PMID: 26898469 DOWNLOAD
*Sun X, *Brieno-Enriquez M.A., *Cornelius A., Modzelewski A.J. Maley T.T., Campbell-Peterson K.M., Holloway J.K., & Cohen, P.E. FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma 125:237-252 (2016) PMID: 26490168 *These authors contributed equally to this work DOWNLOAD
Brieno-Enriquez M.A. & Cohen P.E. Double trouble in human aneuploidy. Nature Genetics 47 (7): 696-698 (2015) PMID: 26111508 DOWNLOAD
Modzelewski A.J., Hilz S., Crate E.A., Schweidenback C.T., Fogarty E.A., Grenier J.K., Freire, R., Cohen P.E., Grimson A. Dicer and Dgcr8 are essential for sex chromosome integrity in male meiosis. Journal of Cell Science. 128 (12): 2314-2327 (2015) PMID: 25934699 DOWNLOAD
Holloway J.K., Sun X., Yokoo R., Villeneuve A.M., Cohen P.E. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precursor crossover sites. Journal of Cell Biology 205: 633-641 (2014) PMID: 24891606 DOWNLOAD
Qiao H, Prasada Rao HB, Yang Y, Fong JH, Cloutier JM, Deacon DC, Nagel KE, Swartz RK, Strong E, Holloway JK, Cohen PE, Schimenti J, Ward J, Hunter N. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nature Genetics 46: 194-199. (2014) PMID: 24390283 DOWNLOAD
Auton A, Rui Li Y, Kidd J, Oliveira K, Nadel J, Holloway JK, Hayward JJ, Cohen PE, Greally JM, Wang J, Bustamante CD, Boyko AR. Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs. PLoS Genetics; 9(12):e1003984 (2013) PMID: 24348265 DOWNLOAD
Pinto RM, Dragileva E, Kirby A, Lloret A, Lopez E, St Claire J, Panigrahi GB, Hou C, Holloway K, Gillis T, Guide JR, Cohen PE, Li GM, Pearson CE, Daly MJ, Wheeler VC. Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches. PLoS Genetics; 9(10):e1003930. (2013) DOWNLOAD
Zhang J., Bonasio R., Strino F., Kluger Y., Holloway J.K., Modzelewski A.J., Cohen P.E., and Reinberg D. SFMBT1 Functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. Genes & Development 27(7);749-766 (2013) PMID: 23592795 DOWNLOAD
Reynolds A., Qiao H., Yank Y., Chen J.K., Jackson N., Biswas K., Holloway J.K., Baudat F., DeMassy B., Wang J., Hoog C., Cohen P.E., & Hunter N. . RNF212 is a haploinsufficient regulator of crossing-over during mammalian meiosis. Nature Genetics. 45(3): 269-278 (2013) PMID: 23396135 DOWNLOAD
Lyndaker A.M, Lim P.X., Mleczko J.M., Diggins C.E., Holloway J.K., Holmes R.J., Kan R., Schlafer D.H., Freire R., Cohen P.E., & Weiss R.S. Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance PLoS Genetics. Feb;9(2):e1003320 (2013) PMID: 23468651 DOWNLOAD
Sun X, Wu X., & Cohen P.E. Non-human primates exhibit errors in meiosis I. Molecular Reproduction and Development 79: 665 (2012). PMID: 22968934 DOWNLOAD
Sun X. & Cohen P.E. Studying recombination in mouse oocytes. Methods in Molecular Biology 957: 1-18 (2012). PMID: 23138941 DOWNLOAD
Modzelewski A.J., Holmes R.J., Hilz S., Grimson A., Cohen P.E. AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Developmental Cell. 23: 251-264 (2012) DOWNLOAD
Holloway J.K., Mohan S., Balmus G., Sun X., Modzelewski A., Borst P.L., Freire R. Weiss R.S., Cohen P.E. Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS Genetics 7(6): e1002094 (2011) DOWNLOAD
Holloway J.K., Roberson E.K., Corbett K., Kolas N.K., Cohen P.E. NEK1 facilitates cohesin removal during mammalian spermatogenesis. Genes 2(1): 260-279 (2011) DOWNLOAD
Cohen P.E., Holloway J.K. Computational approaches to modeling gene networks in human meiosis. Biology of Reproduction 82: 469-472 (2010) PMID: 20032284 DOWNLOAD
Holloway J.K., Morelli M.A., Cohen P.E. The Mouse Ortholog of the Human Bloom's Syndrome Mutated (BLM) is Critical for Integrating Multiple Pathways of Recombination during Meiosis. Journal of Cell Biology 188: 779-789 (2010). PMID: 20308424 DOWNLOAD
Paduch D.A., Bolyakov A., Cohen P.E., Travis A.J. Reproduction in men with Klinefelter syndrome: the past, the present, and the future. Seminars in Reproductive Medicine. 27(2):137-48 (2009).
Kan R., Sun X., Kolas N.K., Wei K., Edelmann W, and Cohen P.E. Disruption of meiotic metaphase I in female mice carrying mutations in various components of the mismatch repair pathway. Biology of Reproduction. 78:462-471 (2008). PMID: 18057311 DOWNLOAD
Avdievich E., Reiss C., Scherer S.S., Jin B., Cohen P.E., Edelmann W. and Kneitz B. Distinct effects of an MLH1 ATPase mutation on MMR functions, cancer and meiosis. Proceedings of the National Academy of Sciences U.S.A. 105(11):4247-52. (2008). PMID: 18337503 DOWNLOAD
Svetlanov A., Baudat F., Cohen P.E., and DeMassy B. Distinct functions of MLH3 at recombination hot spots in the mouse. Genetics 178: 1937–1945 (2008). PMID: 18430927 DOWNLOAD
Morelli M., Werling U., Edelmann W., Roberson M.S., Cohen P.E. Analysis of Meiotic Prophase I in Live Mouse Spermatocytes. Chromosome Research 16: 743-760 (2008). PMID: 18516692 DOWNLOAD
Holloway J.K., Booth J., Edelmann W., McGowan C.H., Cohen P.E. MUS81 generates a subset of MLH1-MLH3 independent crossovers in mammalian meiosis. PLoS Genetics 4(9):e1000186 (2008). PMID: 18787696 DOWNLOAD
Roa S. , Avdievich E., Peled J., MacCarthy T., Werling U., Kuang F.L., Kan R., Zhao C., Bergman A., Cohen P.E., Edelmann W., Scharff M.D. Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proceedings of the National Academy of Sciences U.S.A. 105(42):16248-53 (2008). PMID: 18854411 DOWNLOAD
Holmes, R.J. and Cohen, P.E. Small RNAs and the RNAi pathway in meiotic prophase I. Chromosome Research 15:653-665 (2007). PMID: 17674152 DOWNLOAD
Li Z., Peled J.U., Zhao C., Svetlanov A., Ronai D., Cohen P.E., and Scharff M.D. A role for MLH3 in somatic hypermutation. DNA Repair 5: 675-682 (2006). PMID: 16564751 DOWNLOAD
Cohen P.E., Pollack S.E. and Pollard J.W. Genetic analysis of chromosome pairing, recombination and cell cycle control during the first meiotic prophase in mammals. Endocrine Reviews 27: 398-426 (2006). PMID: 16543383 DOWNLOAD
Lenzi, M., Smith, J., Snowden, T., Kim, M., Fishel, R., Poulos, B., and Cohen, P.E. Extreme heterozygosity in the molecular events leading to the establishment of chiasmata during meiosis I in human oocytes. American Journal of Human Genetics 76 (1): 11-127 (2005). PMID: 15558497 DOWNLOAD
Li, B., Nair, M., Mackay, D.R., Bilanchone, V., Hu, M., Fallahi, M., Song, H., Dai, Q., Cohen, P.E. and Dai, X. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development 132(6): 1463-1473 (2005). PMID: 15716349
§Kolas, N.K., §Svetlanov, A., Lenzi, M., Smith, J., Macaluso, F.P., Greally, J.M., Edelmann, W., Liskay, R.M., Lipkin, S.M., and Cohen, P.E. Distinct functions of MutL homologs in reciprocal recombination and gene conversion in mammalian meiosis. §These authors contributed equally to this work. Journal of Cell Biology 171(3): 447-458 (2005). PMID: 16260499 DOWNLOAD
Morelli, M.A. and Cohen, P.E. Not all germ cells are created equal: aspects of sexual dimorphism in mammalian meiosis. Reproduction 130: 761-781 (2005). PMID: 16322537 DOWNLOAD
Svetlanov, A., and Cohen, P.E. Mismatch repair proteins, meiosis, and mice: understanding the complexities of mammalian meiosis. Experimental Cell Research 296(1): 71-79 (2004) DOWNLOAD
Kolas, N.K., and Cohen, P.E. Novel and diverse function of the DNA mismatch repair family in mammalian meiosis and recombination. Cytogenetic and Genome Research 107: 216-231 (2004). DOWNLOAD
Wei K., Clark A.B., Wong E., Kane M.F., Mazur D.J., Parris T., Kolas N.K., Russell R., Kneitz B., Kunkel T.A., Kolodner R.D., Cohen P.E. & Edelmann W. Inactivation of exonuclease I in mice results in DNA mismatch repair defects, increased cancer susceptibility and male and female sterility. Genes and Development 17(5): 603-614 (2003). DOWNLOAD
§Crackower, M., §Kolas, N., Noguchi, J., Sarao, R., Kikuchi, K., Kaneko, H., Kobayashi, E., Kawai, Y., Kozieradzki, I., Landers, R., Mo, R., Hui, C., Nieves, E., Cohen, P.E., Osborne, L., Wada, T., Kunieda, T., Moens, P.B., and Penninger, J.M. Essential Role of Fkbp6 in Male Fertility and Homologous Chromosome Pairing in Meiosis. § These authors contributed equally to this work. Science 300:1291-1295 (2003). DOWNLOAD
Moens P.B., Kolas N.K., Tarsounas M., Marcon E., Cohen P.E. and Spyropoulos B. The time course and localization of recombination-related proteins at meiosis in the mouse conform to models that can resolve the early DNA-DNA interactions without reciprocal recombination. Journal of Cell Science 115: 1611-1622 (2002). DOWNLOAD
Lipkin S.M., Moens P.B., Wang V., Lenzi M., Shanmugarajah D., Gilgeous A., Thomas J., Cheng J., Touchman J.W., Green E.D., Schwartzberg P., Collins F.S. & Cohen P.E. Meiotic arrest and aneuploidy in Mlh3-defcient mice. Nature Genetics 31(4): 385-390 (2002). DOWNLOAD
Cohen P.E., Zhu, L., Nishimura, K. & Pollard, J.W. Colony stimulating factor-1 (CSF-1) regulation of neuroendocrine pathways that control gonadal function. Endocrinology 143: 1413-1422 (2002). Cohen, P.E. & Pollard, J.W. Regulation of meiotic recombination and prophase I progression in mammals. BioEssays, 23: 996-1009 (2001). DOWNLOAD
§Kneitz B., §Cohen P.E., Avdievich E., Zhu L., Kane M.F., Hou H., Kolodner R.D., Pollard J.W., Kucherlapati R. & Edelmann W. MutS homolog 4 (MSH4) localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. § These authors contributed equally to this work. Genes and Development. 14: 1085-1097 (2000). DOWNLOAD
Zindy, F., Den Besten, W., Chen, B., Latres, E., Barbacid, M., Sherr, C.J., Pollard, J.W., Cohen P.E., & Roussel, M.F. The cyclin-dependent kinase inhibitors, INK4c and INK4d, control spermatogenesis in mice. Molecular and Cellular Biology 21: 3244-3255 (2000). DOWNLOAD
§Edelmann W., §Cohen P.E., Kneitz B., Winand N., Heyer J., Kolodner R., Pollard J.W. & Kucherlapati R. Mammalian MutS homolog 5 is required for chromosome pairing in meiosis. § These authors contributed equally to this work. Nature Genetics 21: 123-127 (1999). DOWNLOAD
Cohen P.E., Nishimura K., Zhu L. & Pollard J.W. Macrophages: Important accessory cells for reproduction. Journal of Leukocyte Biology 66: 765-772 (1999). Cohen P.E. & Pollard J.W. Normal sexual function in male mice lacking a functional type I interleukin-1 receptor. Endocrinology 139: 815-818 (1998).
Edelmann W., Yang K., Umar A., Heyer J., Lau K., Fan K., Liedtke W., Cohen P.E., Kane M.F., Lipford J.R., Yu N., Crouse G., Pollard J.W., Kunkel T., Lipkin M., Kolodner R. & Kucherlapati R. Mutation in the mismatch repairgene MSH6 causes cancer susceptibility. Cell 91: 467-477 (1997). DOWNLOAD
Cohen P.E., Zhu L. & Pollard J.W. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biology of Reproduction 56: 110-119 (1997).
Pollard J.W., Dominguez M.G., Mocci S., Cohen P.E. & Stanley E.R. Effect of the colony stimulating factor-1 (CSF-1) null mutation, osteopetrotic (csfmop), on the distribution of macrophages in the male reproductive tract. Biology of Reproduction 56: 1290-1300 (1997).
Cohen P.E., Hardy M.P. & Pollard J.W. CSF-1 plays a major role in the development of reproductive function in male mice. Molecular Endocrinology 11: 1636-1650 (1997).
Cohen P.E., Chisholm O., Arceci R.J., Stanley E.R. & Pollard J.W. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biology of Reproduction 55: 310-317 (1996).
Cohen P.E. & Pollard J.W. Cytokines and growth factors in reproduction. In: Reproductive Immunology (Bronson R.A., Alexander N.J., Anderson D., Branch D.W., & Kutteh W.H., editors). Blackwell Science, Cambridge, MA. Chapter 3, pages 52-102 (1996).
Edelmann W., Cohen P.E., Kane M., Lau K., Morrow B., Bennett S., Umar A., Kunkel T., Cattoretti G., Chaganti R., Pollard J.W., Kolodner R.D. & Kucherlapati R. Meiotic pachytene arrest in MLH-1-deficient mice. Cell 85: 1125-1134 (1996). DOWNLOAD
Milligan S.R., Cohen P.E. & Finn C.A. The minimum requirements for oestradiol to induce uterine sensitivity for implantation and decidualization in mice. Human Reproduction 10: 1502-1506 (1995).
Cohen P.E. & Pollard J.W. Use of the osteopetrotic mouse for studying macrophages in the reproductive tract. In: Immunobiology of Reproduction (J.S. Hunt, editor). Springer-Verlag, New York. Chapter 8, pages 104-122 (1994).
Cohen P.E. & Milligan S.R. Silastic implants for delivery of oestradiol to mice. Journal of Reproduction and Fertility 99: 219-223 (1993).
