Post-translational control of protein function during meiosis

 

Understanding the role of the SKP1-Cullin-FBox (SCF) complex in meiotic prophase I

The lab's most recent work on CNTD1 was published in Cell Reports on July 7th, 2020. In this study, we identified several components of SCF that function with CNTD1 to regulate cell cycle progression. The SCF complex is a member of the largest family of ubiquitin E3 ligase complexes, and we are interested in understanding what role this complex might have in mediating prophase I progression, as well as determining the ubiqyitylation targets of the complex.