The lab's most recent work on CNTD1 was published in Cell Reports on July 7th, 2020. The work was carried out by Dr. Steve Gray, a former postdoc. Steve made a dual tagged allele of Cntd1 by CRISPR/Cas9 and was able to demonstrate localization of CNTD1 to nascent crossover sites during pachynema of prophase I. Interestingly, Western blot analysis of the tagged protein revealed a smaller than expected protein for endogenous CNTD1, while yeast two-hybrid, immunoprecipitation-western blotting, and mass spectrometry all indicated that this short form CNTD1 does not interact with any known cyclin-dependent kinases. Instead, endogenous mouse CNTD1 appears to interact with two functionally relevant protein complexes during prophase I: the Replication factor C (RFC) complex and the SKP1-Cullin-Fbox (SCF) complex. Through these interactions, we propose that CNTD1 controls both crossing over (by regulating MLH1-MLH3 function through RFC-PCNA interactions) and cell cycle control (through ubiquitylation by SCF of the key cell cycle regulator, WEE1).